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1

Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors

Irini Akritopoulou-Zanze, Daria Darczak, Kathy Sarris, Kathleen M. Phelan, Jeffrey R. Huth, Danying Song, Eric F. Johnson, Yong Jia, Stevan W. Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 119 KB

english, 2006

2

De Novo Design, Synthesis and Biological Evaluation of 3, 4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors

Wang, Ying, Zhao, Hongyu, Brewer, Jason T., Li, Huanqiu, Lao, Yanbin, Amberg, Willi, Behl, Berthold, Akritopoulou-Zanze, Irini, Dietrich, Justin, lange, Udo E. W., Pohlki, Frauke, Hoft, Carolin, Hornb

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.19 MB

english, 2018

3

Isocyanide-based multicomponent reactions in drug discovery

Irini Akritopoulou-Zanze

Journal:

Current Opinion in Chemical Biology

Year:

2008

Language:

english

File:

PDF, 1.35 MB

english, 2008

4

Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins

Nicos A. Petasis, Irini Akritopoulou-Zanze, Valery V. Fokin, Giovanni Bernasconi, Raquel Keledjian, Rong Yang, Jasim Uddin, Kalyan C. Nagulapalli, Charles N. Serhan

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2005

Language:

english

File:

PDF, 903 KB

english, 2005

5

Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils

Serhan, Charles N., Maddox, Jane F., Petasis, Nicos A., Akritopoulou-Zanze, Irini, Papayianni, Aikaterina, Brady, Hugh R., Colgan, Sean P., Madara, James L.

Journal:

Year:

1995

Language:

english

File:

PDF, 904 KB

english, 1995

6

Configuration of heptopyranoside and heptofuranoside side chains: 2-anthroate, a powerful chromophore for exciton coupled CD

Irini Akritopoulou-Zanze, Koji Nakanishi, Halszka Stepowska, Barbara Grzeszczyk, Aleksander Zamojski, Nina Berova

Journal:

Year:

1997

Language:

english

File:

PDF, 346 KB

english, 1997

7

ChemInform Abstract: Synthesis of Substituted Fused Pyridines, Pyrazines and Pyrimidines by Sequential Ugi/Inverse Electron Demand Diels—Alder Transformations.

Irini Akritopoulou-Zanze, Ying Wang, Hongyu Zhao, Stevan W. Djuric

Journal:

Year:

2010

File:

PDF, 35 KB

2010

8

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

Irini Akritopoulou-Zanze, Jyoti R Patel, Kresna Hartandi, Jehrod Brenneman, Martin Winn, John K Pratt, Marlene Grynfarb, Annika Goos-Nisson, Thomas W von Geldern, Philip R Kym

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 279 KB

english, 2004

9

Corrigendum to “1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors” [Bioorg. Med. Chem. Lett. 16 (2006) 4266–4271]

Jürgen Dinges, Kimba L. Ashworth, Irini Akritopoulou-Zanze, Lee D. Arnold, Steven A. Baumeister, Peter F. Bousquet, George A. Cunha, Steven K. Davidsen, Stevan W. Djuric, Vijaya J. Gracias, Michael R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 70 KB

english, 2007

10

Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors

Vijaya Gracias, Zhiqin Ji, Irini Akritopoulou-Zanze, Cele Abad-Zapatero, Jeffrey R. Huth, Danying Song, Philip J. Hajduk, Eric F. Johnson, Keith B. Glaser, Patrick A. Marcotte, Lori Pease, Nirupama B.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 437 KB

english, 2008

11

Synthesis and antibacterial activity of novel bifunctional macrolides

Irini Akritopoulou-Zanze, Kathleen M Phelan, Thomas G Marron, Hong Yong, Zhenkun Ma, Greg G Stone, Melissa M Daly, Dena M Hensey, Angela M Nilius, Stevan W Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 283 KB

english, 2004

12

Topography-biased compound library design: the shape of things to come?

Irini Akritopoulou-Zanze, James T. Metz, Stevan W. Djuric

Journal:

Drug Discovery Today

Year:

2007

Language:

english

File:

PDF, 983 KB

english, 2007

13

ChemInform Abstract: Applications of Isocyanides in the Synthesis of Heterocycles

Akritopoulou-Zanze, Irini

Journal:

Year:

2013

File:

PDF, 18 KB

2013

14

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Irini Akritopoulou-Zanze, Daniel H. Albert, Peter F. Bousquet, George A. Cunha, Christopher M. Harris, Maria Moskey, Jurgen Dinges, Kent D. Stewart, Thomas J. Sowin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

15

Small Molecule Library Synthesis Using Segmented Flow

Thompson, Christina M., Poole, Jennifer L., Cross, Jeffrey L., Akritopoulou-Zanze, Irini, Djuric, Stevan W.

Journal:

Year:

2011

Language:

english

File:

PDF, 174 KB

english, 2011

16

ChemInform Abstract: Applications of MCR-Derived Heterocycles in Drug Discovery

Irini Akritopoulou-Zanze, Stevan W. Djuric

Journal:

Year:

2011

File:

PDF, 18 KB

2011

17

Kinase-targeted libraries: The design and synthesis of novel, potent, and selective kinase inhibitors

Irini Akritopoulou-Zanze, Philip J. Hajduk

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 1.43 MB

english, 2009

18

Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors

Jürgen Dinges, Irini Akritopoulou-Zanze, Lee D. Arnold, Teresa Barlozzari, Peter F. Bousquet, George A. Cunha, Anna M. Ericsson, Nobuhiko Iwasaki, Michael R. Michaelides, Nobuo Ogawa, Kathleen M. Phel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 193 KB

english, 2006

19

Synthesis of substituted 3,4-dihydroquinolin-2(1H)-one derivatives by sequential Ugi/acrylanilide [6π]-photocyclizations

Irini Akritopoulou-Zanze, Alan Whitehead, Jan E. Waters, Rodger F. Henry, Stevan W. Djuric

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 247 KB

english, 2007

20

When analoging is not enough: scaffold discovery in medicinal chemistry

Zhao, Hongyu, Akritopoulou-Zanze, Irini

Journal:

Expert Opinion on Drug Discovery

Year:

2010

Language:

english

File:

PDF, 409 KB

english, 2010

21

Organotitanium compounds in organic synthesis

Petasis, N. A., Lu, S.-P., Bzowej, E. I., Fu, D.-K., Staszewski, J. P., Akritopoulou-Zanze, Irini, Patane, M. A., Hu, Y.-H.

Journal:

Pure & Applied Chemistry

Year:

1996

Language:

english

File:

PDF, 288 KB

english, 1996

22

Theoretical and experimental CD of conformationally flexible complex molecules—application to ouabain pentanaphthoate and analogs

Jian-Guo Dong, Jinsong Guo, Irini Akritopoulou-Zanze, Akira Kawamura, Koji Nakanishi, Nina Berova

Journal:

Year:

1999

Language:

english

File:

PDF, 398 KB

english, 1999

23

Synthesis of substituted fused pyridines, pyrazines and pyrimidines by sequential Ugi/inverse electron demand Diels–Alder transformations

Irini Akritopoulou-Zanze, Ying Wang, Hongyu Zhao, Stevan W. Djuric

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 2.23 MB

english, 2009

24

1,4-Dihydroindeno[1,2- c ]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel

Dinges, Jürgen, Albert, Daniel H., Arnold, Lee D., Ashworth, Kimba L., Akritopoulou-Zanze, Irini, Bousquet, Peter F., Bouska, Jennifer J., Cunha, George A., Davidsen, Steven K., Diaz, Gilbert J., Djur

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 391 KB

english, 2007

25

Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions

Irini Akritopoulou-Zanze, Brian D. Wakefield, Alan Gasiecki, Douglas Kalvin, Eric F. Johnson, Peter Kovar, Stevan W. Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 629 KB

english, 2011

26

Synthesis and Antibacterial Activity of Novel Bifunctional Macrolides.

Irini Akritopoulou-Zanze, Kathleen M. Phelan, Thomas G. Marron, Hong Yong, Zhenkun Ma, Greg G. Stone, Melissa M. Daly, Dena M. Hensey, Angela M. Nilius, Stevan W. Djuric

Journal:

Year:

2004

Language:

english

File:

PDF, 15 KB

english, 2004

27

Synthesis of novel fused isoxazoles and isoxazolines by sequential Ugi/INOC reactions

Irini Akritopoulou-Zanze, Vijaya Gracias, Joel D Moore, Stevan W Djuric

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 242 KB

english, 2004

28

A Versatile Synthesis of Fused Triazolo Derivatives by Sequential Ugi/Alkyne—Azide Cycloaddition Reactions.

Irini Akritopoulou-Zanze, Vijaya Gracias, Stevan W. Djuric

Journal:

Year:

2005

File:

PDF, 31 KB

2005

29

Synthesis and Biological Evaluation of Novel, Selective, Nonsteroidal Glucocorticoid Receptor Antagonists.

Irini Akritopoulou-Zanze, Jyoti R. Patel, Kresna Hartandi, Jehrod Brenneman, Martin Winn, John K. Pratt, Marlene Grynfarb, Annika Goos-Nisson, Thomas W. von Geldern, Philip R. Kym

Journal:

Year:

2004

File:

PDF, 131 KB

2004

30

Concise Construction of Novel Bridged Bicyclic Lactams by Sequenced Ugi/RCM/Heck Reactions

Ribelin, Timothy P., Judd, Andrew S., Akritopoulou-Zanze, Irini, Henry, Rodger F., Cross, Jeffrey L., Whittern, David N., Djuric, Stevan W.

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 173 KB

english, 2007

31

Synthesis of Novel and Uniquely Shaped 3-Azabicyclo[4.2.0]octan-4-one Derivatives by Sequential Ugi/[2+2] Ene−Enone Photocycloadditions

Akritopoulou-Zanze, Irini, Whitehead, Alan, Waters, Jan E., Henry, Rodger F., Djuric, Stevan W.

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 98 KB

english, 2007

32

A versatile synthesis of fused triazolo derivatives by sequential Ugi/alkyne-azide cycloaddition reactions

Irini Akritopoulou-Zanze, Vijaya Gracias, Stevan W. Djuric

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 261 KB

english, 2004

33

An expedient route to diaza-spirocycles utilizing a sequential multicomponent α-aminoallylation/ring-closing metathesis strategy

Vijaya Gracias, Alan F. Gasiecki, Joel D. Moore, Irini Akritopoulou-Zanze, Stevan W. Djuric

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 142 KB

english, 2006

34

Recent Advances in the Development and Applications of Post-Ugi Transformations

Akritopoulou-Zanze, Irini, W. Djuric, Stevan

Journal:

Year:

2007

Language:

english

File:

PDF, 296 KB

english, 2007

35

Scaffold oriented synthesis. Part 3: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions

Irini Akritopoulou-Zanze, Brian D. Wakefield, Alan Gasiecki, Douglas Kalvin, Eric F. Johnson, Peter Kovar, Stevan W. Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

36

Synthesis of Novel Fused Isoxazoles and Isoxazolines by Sequential Ugi/INOC Reactions.

Irini Akritopoulou-Zanze, Vijaya Gracias, Joel D. Moore, Stevan W. Djuric

Journal:

Year:

2004

File:

PDF, 143 KB

2004

37

The Use of Three-Dimensional Shape and Electrostatic Similarity Searching in the Identification of a Melanin-Concentrating Hormone Receptor 1 Antagonist

Steven W. Muchmore, Andrew J. Souers, Irini Akritopoulou-Zanze

Journal:

Chemical Biology & Drug Design

Year:

2006

Language:

english

File:

PDF, 1.31 MB

english, 2006

38

Solid-Phase Synthesis of Macrolide Analogues

Akritopoulou-Zanze, Irini, Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 109 KB

english, 2001

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